Mixing Gabapentin and Xanax

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You may wonder “Can I take Xanax with gabapentin?”
Combining gabapentin and Xanax can be quite dangerous and should be avoided unless specifically prescribed by a doctor with full knowledge of both medications and your individual health status. Taking both medicines together can lead to risk of addiction, anxiety and negative side effects. Since both medications have sedative (drowsiness) effects, taking them together can significantly increase sedation - which can lead to several dangerous side-effects.

Dangers Of Mixing Gabapentin and Xanax

The dangers of mixing gabapentin and Xanax include:

  • Impaired coordination and balance: Combining Xanax and gabapentin elevates the risk of falls and accidents, posing a heightened danger to physical safety. 
  • Cognitive problems: The mixture of gabapentin and Xanax increases the risk of cognitive impairment, potentially leading to poor decision-making and risk-taking.
  • Confusion and disorientation: Combining the two medicines increases confusion and disorientation, especially in elderly patients.
  • Respiratory depression: In severe cases, slowed breathing may occur, posing a serious risk that could be life-threatening. 

If you or a loved one suffers from an addiction to prescription drugs, reach out to us at Avenues Recovery so we can guide you on your road to recovery.

What Is Gabapentin? 

Gabapentin is an anticonvulsant medication primarily used to treat seizures and neuropathic pain. It works by affecting the way nerves send messages to the brain. While its exact mechanism of action is not fully understood, it is believed to modulate the activity of certain neurotransmitters.

Here are some common uses of gabapentin: 

  • Epilepsy: Gabapentin is approved for the treatment of partial seizures in adults and children. 
  • Neuropathic pain: Gabapentin is often prescribed to manage nerve pain caused by conditions such as diabetic nerve pain (neuropathy), nerve pain following shingles, and other forms of nerve pain. 
  • Restless Legs Syndrome (RLS): Gabapentin may be used to relieve symptoms of restless legs syndrome. 

Side Effects Of Gabapentin:

As with any medication, gabapentin can cause side effects. It's important to note that not everyone will experience these side effects, and their severity may vary.

Common side effects of gabapentin may include: 

  • Tiredness or weakness
  • Dizziness
  • Vomiting
  • Diarrhea
  • Weight gain
  • Mood changes
  • Swollen arms and legs
  • Headaches
  • Memory problems

Serious side effects of gabapentin are rare but can include:

  • Allergic reactions
  • Severe dizziness
  • Swelling of the face
  • Swelling of the throat

It's important to contact a healthcare professional if you experience any severe or persistent side effects.

What Is Xanax?

Xanax is a brand name for the medication alprazolam, which belongs to a class of drugs called benzodiazepines (benzos). Xanax works by enhancing the effects of a natural brain chemical called gamma-aminobutyric acid (GABA). GABA helps to calm down the central nervous system, and by increasing its activity, Xanax can reduce anxiety and promote relaxation. Xanax is primarily used to treat anxiety disorders, including: 

Generalized anxiety disorder (GAD): Characterized by excessive worry and tension about everyday life.

Panic disorder: Sudden episodes of intense fear and apprehension accompanied by physical symptoms like a racing heart, shortness of breath, and dizziness. 

Social anxiety disorder: Significant anxiety or fear in social situations, which interferes with daily life. 

Common Side effects of Xanax

The most common side effects of Xanax include: 

  • Drowsiness and fatigue: This is the most frequent side effect, especially at higher doses. It can impact coordination and alertness, increasing the risk of accidents.
  • Dizziness and lightheadedness: This can occur when first taking Xanax or when changing positions suddenly. 
  • Impaired coordination and balance: This can hinder activities like driving or operating machinery. 
  • Memory problems and confusion: Short-term memory and focus can be affected, causing forgetfulness or difficulty concentrating.
  • Muscle weakness and tremors: These may be mild or more pronounced, impacting daily activities. 
  • Slurred speech and difficulty speaking: The sedative effects of Xanax can affect speech clarity and articulation. 
  • Headaches and nausea: These are relatively common side effects that usually don't require medical attention unless severe or persistent. 
  • Sleep problems: While Xanax can initially induce sleepiness, it can disrupt sleep patterns in the long run, leading to insomnia or nightmares. 
  • Dry mouth: Xanax can cause dry mouth, which can be uncomfortable and cause difficulty swallowing. 

Less Common Side Effects of Xanax 

Aside from the side effects mentioned above, some less common but potentially grave side effects of Xanax may include: 

  • Mood changes and suicidal thoughts: Xanax can worsen pre-existing depression or anxiety and, in rare cases, contribute to suicidal thoughts and behaviors. 
  • Increased anxiety: For some individuals, Xanax (especially the short-acting version) can worsen anxiety symptoms or trigger panic attacks. 
  • Addiction and withdrawal symptoms: Xanax has a high potential for dependence and misuse. Abruptly stopping it can lead to withdrawal symptoms like seizures, tremors, hallucinations, and severe anxiety. 
  • Allergies and allergic reactions: While rare, allergic reactions to Xanax can occur, ranging from mild rash to life-threatening anaphylaxis.

How Long After Gabapentin Can You Take Xanax? 

Most doctors do not recommend taking Gabapentin and Xanax at the same time due to the potential of highly sedative effects when taken together. If you have been prescribed both medicines separately, ask your healthcare professional how long to wait in between each one to avoid negative side effects.

Gabapentin vs. Xanax for Sleep Disorders

Choosing between gabapentin and Xanax for sleep involves considering their pros and cons. Gabapentin, a non-benzos drug, has a lower risk of dependence and may be safer for long-term use. Despite being used off-label for insomnia, its effectiveness is still under study, and individual responses vary. Common side effects include dizziness and drowsiness.

On the other hand, Xanax, a benzodiazepine, acts quickly and is helpful for acute insomnia or anxiety-related sleep issues. However, it comes with the risk of dependence, changes in sleep patterns, and cognitive impairment. The decision should be made based on an individual's specific situation and preferences, considering factors like medical history and the desired balance between effectiveness and potential side effects. Seeking guidance from a healthcare professional is essential for personalized advice on managing sleep disorders. 

Gabapentin vs. Xanax



Xanax (Alprazolam)

Drug Class

Anticonvulsant, neuropathic pain reliever


Primary Uses

Epilepsy, post shingles nerve pain, hot flashes (off-label), Neuropathic Pain (off-label

Anxiety disorders, panic attacks, insomnia (short-term)

Mechanism of Action

Enhances calcium influx in nerve cells, reducing neurotransmitter release

Enhances GABA activity in the brain, promoting relaxation and reducing anxiety

Addiction Potential



Withdrawal Symptoms

Uncommon, mild dizziness or fatigue

Common, severe (seizures, tremors, hallucinations)

Side Effects

Drowsiness, dizziness, fatigue, body aches, unsteadiness, memory problems

Drowsiness, dizziness, fatigue, slurred speech, impaired coordination, muscle weakness, depression, anxiety

Dosage Frequency

3-4 times per day

2-3 times per day, as needed for panic attacks

Duration of Use

Long-term use often recommended

Short-term use recommended (2-4 weeks)

Controlled substance

Only in some states

Schedule IV


Treatment for Gabapentin and Xanax Abuse

Treatment for Gabapentin and Xanax abuse involves a comprehensive approach that includes medical detoxification, behavioral therapy, and support groups. Medical detoxification is often the first step, where healthcare providers carefully taper (lower) the dosage of Gabapentin and Xanax to minimize withdrawal symptoms.

Behavioral therapies such as cognitive-behavioral therapy (CBT) and motivational interviewing (MI) are essential components of treatment, helping people understand and change their behaviors related to drug abuse.

Support groups like Narcotics Anonymous (NA) or SMART Recovery can provide ongoing support and encouragement from others in recovery. In some cases, medication-assisted treatment (MAT) may be used to manage withdrawal symptoms and cravings. Dual diagnosis treatment may be necessary if the individual has co-occurring mental health disorders.

After completing formal treatment, aftercare programs can help prevent relapse through continued support and monitoring. It's crucial for individuals seeking treatment to work closely with healthcare professionals to develop a personalized treatment plan that meets their specific needs.


If you or a loved one suffers from an addiction to prescription drugs, reach out to us at Avenues Recovery so we can guide you on your road to recovery. Our expert team of addiction specialists have helped thousands of people overcome their addictions, and they can help you too. We offer comprehensive treatment plans incorporating traditional and holistic therapies, in a warm community-like setting. If you are serious about addiction recovery, reach out to us today. Our supportive staff will be at your side every step of the way to the sober future you deserve.

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